A SPECIFIC COMPLEMENT-FIXING ANTIGEN PRESENT IN SV40 TUMOR AND TRANSFORMED CELLS

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Abstract
Suspensions of hamster tumors and various species cells transformed by SV40 contain a specific antigen(s) demonstrable by CF tests with sera of hamsters bearing SV40 tumors. This antigen has several properties which are distinct from the SV40 viral antigen(s); it is soluble, heat labile, and has a different serologic reactivity. These results, taken together with other evidence, support the hypothesis that the new antigen is synthesized by information from SV40 viral genome integrated in the tumor and in vitro transformed cells. Antibody to the "new" cellular antigen appears in the serum of hamsters soon after the development of tumor, and rises in titer as the tumors increase in size. Response to this antigen is largely independent of antiviral antibody response.