RESPIRATORY EFFECTS OF A NEW OPIATE ANALGESIC, R 39209, IN THE RABBIT: COMPARISON WITH FENTANYL

Open Access

1 November 1980

journal article
research article
Published by Elsevier in British Journal of Anaesthesia

Vol. 52 (11) , 1101-1106
https://doi.org/10.1093/bja/52.11.1101

Abstract

The respiratory effects of R 39209, a new short-acting analgesic, were studied and compared with those of fentanyl, in the rabbit. Minute volume, respiratory frequency and pH₃PCO₂ and standard bicarbonate of artcrialized venous blood were measumi R 39209 had an earlier peak effect and shorter duration of action than fentanyl, but otherwise the respiratory effects of the two drugs were similar. Fentanyl was between 2 and 3.5 times more potent than R 39209. Repeated doses of R 39209 produced reproducible peak effects wen when only 10 min was allowed between administranons.

Keywords

OPIOID ANALGESICS
ORYCTOLAGUS CUNICULUS
FENTANYL
ANALGESICS
BICARBONATE THERAPY
CARBON DIOXIDE
RESPIRATORY RATE
DRUG PEAK EFFECT

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