Immune response gene(s) controlling the humoral antilysozyme response (Ir-Lys) linked to the major histocompatibility complexSL-A in the pig

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Abstract
A genetic control of humoral immune response in pigs against hen egg-white lysozyme was shown to be linked to the major histocompatibility complexSLA. This control was detected when high antigen doses were used for immunization. It was more prominent with small immunizing doses of lysozyme. Under these latter conditions,SL- A heterozygous individuals exhibited a higher response than correspondingSL- A homozygous animals, suggesting a complementation phenomenon between several genes, at least one of which is linked to the porcine MHC,SL- A.