A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease
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Open Access
- 9 September 2002
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 196 (6) , 859-865
- https://doi.org/10.1084/jem.20020781
Abstract
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available.Keywords
This publication has 37 references indexed in Scilit:
- Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejectionNephrology Dialysis Transplantation, 2001
- Contribution of the Respiratory Syncytial Virus G Glycoprotein and Its Secreted and Membrane-Bound Forms to Virus Replication in Vitro and in VivoVirology, 2001
- Respiratory Syncytial Virus (RSV)–Induced Airway Hyperresponsiveness in Allergically Sensitized Mice Is Inhibited by Live RSV and Exacerbated by Formalin‐Inactivated RSVThe Journal of Infectious Diseases, 2000
- CD8+ T cells control Th2‐driven pathology during pulmonary respiratory syncytial virus infectionEuropean Journal of Immunology, 1997
- Prophylactic Administration of Respiratory Syncytial Virus Immune Globulin to High-Risk Infants and Young ChildrenNew England Journal of Medicine, 1993
- Neutrophil Recruitment by Tumor Necrosis Factor from Mast Cells in Immune Complex PeritonitisScience, 1992
- Cotton rats previously immunized with a chimeric RSV FG glycoprotein develop enhanced pulmonary pathology when infected with RSV, a phenomenon not encountered following immunization with vaccinia—RSV recombinants or RSVVaccine, 1992
- Immunization of cotton rats with the fusion (F) and large (G) glycoproteins of respiratory syncytial virus (RSV) protects against RSV challenge without potentiating RSV diseaseVaccine, 1989
- Measles-Specific Lymphocyte Reactivity and Serum Antibody in Subjects With Different Measles HistoriesArchives of Pediatrics & Adolescent Medicine, 1980
- Cell-mediated Immunity to Respiratory Syncytial Virus Induced by Inactivated Vaccine or by InfectionPediatric Research, 1976