Rapid estimation of octanol–water partition coefficients using deoxycholate micelles in capillary electrophoresis
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 21,p. 2241-2243
- https://doi.org/10.1039/c39950002241
Abstract
Deoxycholic acid micelles have been used successfully in capillary electrophoresis to estimate the octanol-water partition coefficient (log P) of a number of drugs; the methodology developed is fast and is suitable for the determination of this physico-chemical parameter for neutral, basic and weakly acidic molecules with a variety of structures.Keywords
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