Delayed hyperphagia and increased body length after hypothalamic knife cuts in weanling rats.

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Abstract
In 2 experiments a total of 23 4-wk-old female Carworth albino rats received parasagittal hypothalamic knife cuts. 11 Ss served as sham-operated controls. Polydipsia began in the experimental Ss right after surgery, but hyperphagia, obesity, and excessive nose-anal length did not begin until after the Ss were 7-8 wk old. The delayed onset appears to await some maturational event that is required for the expression of hypothalamic obesity. It appears likely that puberty is the critical maturational event. (49 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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