Studies on chemical carcinogens and mutagens. XXVI. Chemical properties and mutagenicity of alkyl alkanesulfonates on Salmonella typhimurium TA100.

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Abstract
The mutagenic and cytotoxic effects of 18 kinds of methyl, ethyl and isopropyl esters of straight-chain alkanesulfonic acids including isethionic acid were investigated on Salmonella typhimurium TA100. To correlate these biological activities with the chemical and/or physicochemical properties, the hydrolytic rates (as a measure of alkylating ability) and the capacity factors (as a measure of hydrophobicity) were determined. Some structural correlations were apparent, although quantitative structure-activity relationships were not obtained.