Interferon-β Enhances the Synthesis of a 20,000-Dalton Membrane Protein: A Correlation with the Cessation of Cell Growth
- 1 January 1985
- journal article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 5 (2) , 305-313
- https://doi.org/10.1089/jir.1985.5.305
Abstract
Interferons (IFNs)-alpha and -beta but not -gamma enhance the synthesis of a protein in the membranes of Daudi cells. This protein has an estimated molecular weight of 20,000 (20 kD). Furthermore, the 20-kD protein is enhanced only in the membranes of cells whose growth can be inhibited by IFN-beta (Daudi, WISH, HL-60, diploid fibroblasts) but not in the membranes of cells whose growth is not inhibited by IFN-beta (Namalva, Raji). These data suggest a correlation between the IFN-beta-enhanced 20-kD membrane protein and the inhibition of cell growth by IFN-beta.Keywords
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