The Immunoglobulins of Equine Colostrum and Parotid Fluid

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Abstract
Chemical fractionation and antigenic analysis have shown equine parotid fluid and equine colostrum to contain γG, γG(T) and γM immunoglobulins. The immunoglobulins found in the secretions were comparable in size and electrophoretic mobility to the corresponding serum immunoglobulins. Parotid fluid γG(a,b,c) and γG(T) were purified by gel filtration, ion exchange chromatography and sucrose density gradient ultracentrifugation. Purified parotid fluid γG(a,b,c) obtained from a hyperimmunized horse was found to contain precipitating antibodies directed to proteins used in the immunization of the horse. The ratio of γG(a,b,c) to γG(T) immunoglobulins of parotid fluid and colostrum was close to the ratio of these immunoglobulins found in the donor horse's serum. There appears to be little or no secretory γA immunoglobulin in equine parotid fluid or colostrum that is comparable in size and antigenicity to that found in some other mammals.

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