Occurrence of globulin-like migrating blood albumins, or GLIMBAL, in pathological rat and human sera

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Abstract
The presence in the serum of albumins with a globulin-like electrophoretic mobility (globulin-like migrating blood albumins or GLIMBAL) was determined by immunoelectrophoresis in rat and human sera. GLIMBAL were occasionally detected (14%) in rat sera during the acute inflammation induced by yeast injection. GLIMBAL were present in pathological human sera from patients with rheumatoid arthritis (50%), systemic lupus erythematosus (69%), and liver disease (17%). The occurrence of GLIMBAL in human sera is more frequent than previously described. Many pathological conditions are accompanied by electrophoretic changes of serum, consisting of an increase of globulins and eventually albumin decrease; these changes may in some conditions reflect a process of albumin transformation rather than an increase in globulin synthesis.