Some Teratogenic Effects of Vinblastine on the External Morphology of Drosophila melanogaster
- 1 January 1971
- journal article
- oncogenesis
- Published by S. Karger AG in Oncology
- Vol. 25 (2) , 188-192
- https://doi.org/10.1159/000224569
Abstract
Virgin Drosophila melanogaster were mated in culture vials containing Vinblastine, dissolved in distilled water, at concentrations of 0, 0.16, 0.31, 0.63, 1.25, and 2.5 μg/ml. Progeny were examined daily from the 10th through the 17th days. The frequency of teratogenic effects increased with the concentration. A distinct cephalo-caudal gradient of the ectodermal tissue was observed with cephalic anomalies predominating. Eyes, antennae, wings, halteres, head, and thorax showed notable anomalies.Keywords
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