Synthesis and dopaminergic activity of 2-substituted octahydrobenzo[f]quinolines
- 1 May 1989
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 32 (5) , 961-968
- https://doi.org/10.1021/jm00125a007
Abstract
A series of 2-substituted octahydrobenzo[f]quinolines has been synthesized and assayed for dopamine agonist activity. Only the compounds corresponding to the beta-rotameric conformation of dopamine showed biphasic activity in competition binding studies with the radioligand [3H]spiroperidol. These findings suggest that the congeners possessing the beta-rotamer conformation show receptor-binding characteristics that resemble those of the ergolines more closely than do those of the corresponding alpha-rotamer congeners.Keywords
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