A Study of Mechanisms of Post-irradiation Changes in Adenylate-cyclase Activity
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 44 (1) , 31-39
- https://doi.org/10.1080/09553008314550841
Abstract
Hormone-stimulated adenylate-cyclase activity (via β-adrenergic receptors) is reduced after in vitro irradiation of plasma membranes of frog erythrocytes, at a dose (650 Gy) which does not change the number of β-adrenergic receptors but causes an oxidative degradation of membrane lipids. Peroxidation of membrane lipids without irradiation also results in a lesser stimulation of adenylate cyclase by the β-agonist. A possible mechanism of change in adenylate-cyclase functioning is discussed.Keywords
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