An acoustic plate mode device for biosensor applications
- 9 December 2002
- conference paper
- Published by Institute of Electrical and Electronics Engineers (IEEE)
Abstract
Experimental data are presented which show that the dual delay line interferometer consisting of SH-APM (shear horizontal acoustic plate mode) devices is a sensitive analytical tool potentially capable of detecting subnanogram per millimeter quantities of a specific DNA sequence without interference from thermal drift or nonspecific DNA sequences. The APM biosensor was tested with DNA polymers and showed a measurable response at the nanogram level per millimeter of solution. The biosensor is reusable and qualitatively reproducible.<>Keywords
This publication has 2 references indexed in Scilit:
- Nucleic Acid Hybridization Detected by Piezoelectric ResonanceAnalytical Letters, 1988
- Microgravimetric immunoassay with piezoelectric crystalsAnalytical Chemistry, 1983