TISSUE DISTRIBUTION STUDIES WITH RADIOACTIVE MANGANESE - POTENTIAL AGENT FOR MYOCARDIAL IMAGING

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (9) , 933-936
Abstract
Mn, a trace metal, is known to localize in mitochondria. Since mitochondria are abundant in heart muscle, the possible utility of radioactive Mn as a myocardial imaging agent was examined in 25 rats and 6 dogs. Myocardial uptake of 54Mn in rats was found to exceed that of 201Tl; myocardium-to-blood ratios averaged 306:1 vs. 48:1 for Tl-201. In the dog, uptake of 54Mn by ischemic myocardium was reduced by 17-75% compared with normal myocardium. Radioactive Mn appears promising as an i.v. myocardial imaging agent and might be useful in studying the function of myocardial mitochondria by external imaging.

This publication has 8 references indexed in Scilit: