Estrogen-Binding Sites in Endothelial Cell Cultures
- 1 September 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 201 (4358) , 817-819
- https://doi.org/10.1126/science.684408
Abstract
The cytosol extracted from a vascular endothelial cell line binds [3H]estradiol with high affinity and a high degree of specificity. In contrast, in experiments performed with cytosol labeled in the intact cell, progesterone and, to a smaller extent, testosterone gave an apparent inhibition of estradiol binding. These data support the concept that ovarian hormones may influence the role of the endothelium in various physiological and pathophysiological conditions.Keywords
This publication has 6 references indexed in Scilit:
- Menopause and Risk of Cardiovascular DiseaseAnnals of Internal Medicine, 1976
- Hormone and neurotransmitter receptors in an established vascular endothelial cell line.Proceedings of the National Academy of Sciences, 1976
- SOME ATHEROGENIC CONCOMITANTS OF MENOPAUSE: THE FRAMINGHAM STUDYAmerican Journal of Epidemiology, 1976
- Progesterone antagonism of the oestrogen receptor and oestrogen-induced uterine growthNature, 1975
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949