Typological Prediction of Response to Amitriptyline: a Replication Study

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Abstract
This paper reports a replication study of prediction of outcome by a clusteranalysis derived four-group typology of depression. 143 acutely depressed women were treated with amitriptyline for 4 weeks. In replication of the earlier findings, anxious depressives showed the worst response, hostile depressives and young depressives with personality disorder the best, with psychotic depressives intermediate. The findings provide further validating evidence for the typology, and for the view that nonpsychotic depressives are heterogeneous.

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