PH1-POSITIVE ACUTE LYMPHOCYTIC-LEUKEMIA WITH CHROMOSOME 7 ABNORMALITIES

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 49  (2) , 281-287
Abstract
A 56 yr old woman with acute lymphocytic leukemia showed the presence of a Philadelphia chromosome in 90% of the bone marrow metaphases and in 10% of the peripheral blood metaphases. Part of the long arm of a G22 chromosome was translocated to the long arm of a C9 chromosome. A 2nd cytogenetic abnormality was found in chromosome 7. Monosomy 7 was found in 60% of the marrow and in 20% of the peripheral blood metaphases. Chromosome 7q- was also found in a small percentage of the metaphases examined. Three months later, when the patient was in partial remission, only 10% of the marrow cells showed chromosome 7 monosomy and a Ph1 chromosome. During complete remission, no chromosomal abnormalities were found, except for a high breakage rate. The finding of a Ph1 chromosome in acute lymphocytic leukemia indicates that different precursors, both granulocytic and lymphocytic, may be involved in the Ph1 process.

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