Abnormal growth hormone response to LRH and TRH in adolescent schizophrenic boys

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Abstract
The effect of LRH [luliberin, luteinizing hormone-releasing hormone] and TRH [thyroliberin, thyrotropin hormone-releasing hormone] on HGH [growth hormone] in 10 adolescent schizophrenic boys and 9 age-matched normal boys. Before antipsychotic treatment, LRH and TRH induced a marked rise in HGH in 8 of 10 patients and 4 of 6 patients, respectively. No effect on HGH was observed in the normal controls. After 3 mo. of treatment with chlorpromazine, thioridazine or haloperidol, LRH failed to induce a rise in HGH in 5 of the 6 patients tested, but TRH induced a significant rise in HGH in 3 of 4 patients tested. These results may indicate a dysfunction in the mechanism regulating HGH secretion in schizophrenia.