Rigid analogs of acetylcholine can be m1-selective agonists: implications for a rational treatment strategy in Alzheimer's disease
- 31 August 1992
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 2 (8) , 839-844
- https://doi.org/10.1016/s0960-894x(00)80541-7
Abstract
No abstract availableThis publication has 22 references indexed in Scilit:
- Muscarinic receptor-operated Ca2+ influx in transfected fibroblast cells is independent of inositol phosphates and release of intracellular Ca2+.Proceedings of the National Academy of Sciences, 1992
- Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.Proceedings of the National Academy of Sciences, 1991
- Drugs to Treat Age‐Related Neurodegenerative Problems The Final Frontier of Medical Science?Journal of the American Geriatrics Society, 1990
- Reversal of age-related cognitive impairments by an M1 cholinergic agonist, AF102BPharmacology Biochemistry and Behavior, 1990
- Muscarinic Receptor SubtypesAnnual Review of Pharmacology and Toxicology, 1990
- (±)-cis-2-Methyl-spiro(1,3-oxathiolane-5,3′) quinuclidine (AF102B): A new M1 agonist attenuates cognitive dysfunctions in AF64A-treated ratsNeuroscience Letters, 1989
- Dual synaptic effects of activating M1-muscarinic receptors, in superior cervical ganglia of rabbitsBrain Research, 1988
- Effects of fexibility on the dynamics of ligand binding. Time course of action of muscarinic antagonistsJournal of the Chemical Society, Faraday Transactions 2: Molecular and Chemical Physics, 1988
- Amelioration of Experimental Amnesia (Passive Avoidance Failure) in Rodents by the Selective M1 Agonist AF102BThe Japanese Journal of Pharmacology, 1988
- Offset rate of action of muscarinic antagonists depends on their structural flexibilityCellular and Molecular Life Sciences, 1979