Preparation and Use of Concentrated Red Cell Suspensions in Treatment of Anaemia

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Abstract
The plasma to be used for special transfusions is first aspirated by the "closed," aseptic method of Edwards and Davie (Brit. Med. Jour., 1940, 2: 73). The long aspirating needle is then plunged to the bottom of the red cell layer and aspiration of the concentrated red cells is continued aseptically into sterile bottles, great care being taken not to withdraw the surface layer of gelatinous material which consists of leucocytes, platelets and fibrin. The last drops in the needle are used for grouping and cross-matching. Matched red cells from several donors may be combined. Dilution has not been found necessary, as no insuperable transfusion difficulties have been experienced on account of increased viscosity of the concentrated suspensions. Material for 150 transfusions of concentrated red cells has been issued during the past 8 mos. and 77 transfusions given to 61 patients are reported. The frequency of reactions to this form of transfusion is considerably lower than when stored whole blood is used.

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