Pharmacological Studies onLinderae umbellataeRamus, IV*. Effects of Condensed Tannin Related Compounds on Peptic Activity and Stress-Induced Gastric Lesions in Mice
- 26 February 1985
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 51 (01) , 34-38
- https://doi.org/10.1055/s-2007-969386
Abstract
Nine condensed tannin related compounds isolated from Linderae umbellatae Ramus, (+)-catechin (1), (-)-epicatechin (2), proanthocyanidin B-1 (3), B-2 (4), B-4 (5), trimer A (6), trimer B (7), cinnamtannin B1 (8) and cinnamtannin D1 (9), were tested for their effects on peptic activity and stress-induced gastric lesions in mice. Peptic activity of rat gastric juice was suppressed by 6 and 7 in vitro, and slightly suppressed by 8 and 9. In pylorus-ligated mice, these compounds, except for 4, administered orally exhibited anti-peptic activity. Pretreatments of 4,6 and 7 orally protected mice against stress-induced gastric lesions. Effects of these compounds on digestive systems were dìscussed.This publication has 0 references indexed in Scilit: