d-Aldosterone and sweat electrolytes

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Abstract
Men worked (BMR 190 kcal/m2 hr) in the heat (45–50 C D.B.; 26 C W.B.) for periods of 5–7 hr, maintaining water and salt balance by drinking appropriate saline solutions. d-Aldosterone was administered by continuous intravenous infusion at 1.5 µg/kg hr during the third to seventh hours without altering the Na or Cl concentration of the men's sweat from control values determined during the first 2 hr of the exposures, or from the values observed during separate control experiments. Na and Cl concentrations of sweat secreted the day following the infusion experiments were not significantly different from those of samples collected the day after control experiments. The sodium-conserving responses of the men's sweat glands 7–24 hr following salt depletion (-140 to -230 mEq) were not significantly altered by infusion of 2.0–4.5 µg/kg hr of d-aldosterone. Continuous infusion of d-aldosterone at 1.8 µg/kg hr into one brachial artery did not alter the Na or Cl concentration of sweat being secreted by the infused arm, either from simultaneously collected samples from the man's other arm or from control values in both arms before the infusion was started. In all cases, pronounced reductions in urinary Na:K ratios were observed during and after d-aldosterone administration. Submitted on October 28, 1963

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