ASSESSMENT OF FUNCTIONAL ACTIVITY OF HUMAN LYMPHOCYTES IN MALIGNANT DISEASE BY LOCAL GRAFT VERSUS HOST REACTION IN RATS AND T-ROSETTE-FORMING CELL TEST
- 1 January 1976
- journal article
- research article
- Vol. 24 (3) , 534-537
Abstract
The local graft-vs.-host reaction (GVHR) and the spontaneous rosette-forming cell (RFC) test were used to test the functional activity of lymphocytes in blood obtained from 20 normal donors and 30 patients with malignant tumors. The lymphocytes of all 20 control donors gave a positive GVHR and had normal FRC values. In 22 of the 30 patients with malignancies, the GVHR was negative; of these, only 5 had low RFC values. In the remaining 8 patients, the GVHR was positive and RFC values were normal. The local GVHR constitutes a sensitive test for measurement of the functional activity of lymphocytes, while the RFC test can only be used as a quantitative test.This publication has 7 references indexed in Scilit:
- Investigation of the cellular immunocompetence in chronic lymphatic leukemia and malignant lymphoma patients as assessed by the local graft versus host reaction in rats.1974
- Correlation of in vivo and in vitro assays of immunocompetence in cancer patients.1974
- Immunological Rebound after Cessation of Long-term Chemotherapy in Acute Lymphocytic Leukaemia: Changes in Distribution of T and B Cell Populations in Bone Marrow and Peripheral BloodBritish Journal of Haematology, 1974
- AN IN VIVO TEST FOR THE IMMUNOCOMPETENCE OF HUMAN LYMPHOCYTESTransplantation, 1973
- Local graft-versus-host reaction in rats as a clinical assay of immunosuppression.1971
- A LOCAL GRAFT-VERSUS-HOST REACTION FOLLOWING INTRADERMAL INJECTION OF LYMPHOCYTES IN RAT1967
- Quantitative studies on tissue transplantation immunity. VII. The normal lymphocyte transfer reactionProceedings of the Royal Society of London. B. Biological Sciences, 1966