Decarboxylative transamination. A new route to spirocyclic and bridgehead-nitrogen compounds. Relevance to α-amino acid decarboxylases
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 3,p. 182-183
- https://doi.org/10.1039/c39840000182
Abstract
N-Substituted and α,α-disubstituted amino acids react with carbonyl compounds to generate 1,3-dipolar species under mild conditions mimicking α-amino acid decarboxylases; the 1,3-dipoles can be trapped both inter- and intra-molecularly to give bridgehead-nitrogen and spirocycli products in goood yield; pyridoxal is shown to react in an analogous fashion.Keywords
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