Effects of bromocriptine-induced pregnancy on prolactin-secreting pituitary tumours

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Abstract
Twenty-eight women with hyperprolactinemia and amenorrhea received bromocriptine treatment which resulted in 31 term pregnancies. Bromocriptine treatment was stopped as soon as pregnancy was established. Nineteen of the women had radiological signs of a pituitary tumor. The pregnancies were clinically uneventful in all cases except 1 who developed headache. Post-partum sellar X-ray showed pregnancy-induced enlargement of the pituitary fossa in 4 of the 28 women. Regression of the radiological changes occurred in 3 of the 4 women within 2 yr after the delivery. The women with abnormal sellar X-rays had no difference in the mean prolactin levels before treatment and after pregnancy and lactation while all the women with normal sellae had lower prolactin levels after pregnancy than before. Three women resumed regular spontaneous menstruations after pregnancy and lactation but only 1 conceived again. Thus, serious pituitary tumor complications are rare in hyperprolactinemic women with bromocriptine-induced pregnancies. The pregnancy does not worsen the condition. Resolution of hyperprolactinemia after bromocriptine-induced pregnancy is an infrequent finding.

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