Fibroblasts and macrophages of mice with the Chediak-Higashi-like syndrome have microtubules and actin cables.
Open Access
- 1 November 1978
- journal article
- research article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 79 (2) , 401-408
- https://doi.org/10.1083/jcb.79.2.401
Abstract
Cells of the beige mouse contain abnormally large lysosomes and show enhanced capping of concanavalin A. It has been suggested that these phenomena may be secondary to a defect in microtubule polymerization. We have examined the cytoskeleton of beige mouse cells by indirect immunofluorescence and find the number and distribution of microtubules and actin cables to be indistinguishable from those of normal control cells.This publication has 2 references indexed in Scilit:
- Correction of characteristic abnormalities of microtubule function and granule morphology in Chediak-Higashi syndrome with cholinergic agonists.Journal of Clinical Investigation, 1976
- Muscle-Like Contractile Proteins and Tubulin in SynaptosomesProceedings of the National Academy of Sciences, 1974