Antitumor Immunity in the Shope Papilloma-Carcinoma Complex of Rabbits, I. Papilloma Regression Induced by Homologous and Autologous Tissue Vaccines2

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Abstract
A substantial increase in frequency of regression of Shope papillomas occurred in rabbits inoculated with a vaccine made of freshly removed homologous tumor tissue. Spontaneous regression rates in unvaccinated littermate controls were approximately 25 percent; the regression rate in groups of vaccinated animals was usually between 50 and 90 percent. In most experiments Bordetella pertussis cells were included in the vaccine, but vaccines without B. pertussis were equally effective. An autologous tissue vaccine was as effective as homologous tissue vaccine, though that made from homologous tissue stored in glycerine had little activity. The available evidence favors the concept that the regression of papillomas in the system studied is a consequence of a specific immunological reaction against the tumor.

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