CEREBRAL ANEURYSMS AND CONGENITAL ABNORMALITIES

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Abstract
Summary: The prevalence of congenital abnormalities in a series of 215 subjects with cerebral aneurysms proven at autopsy was not significantly greater than that in a control series of 849 subjects or in a series of 351 with non‐aneurysmal cerebral hæmorrhage. Apart from coarctation of the aorta and polycystic kidneys, the incidence was not higher than in the general population.It is concluded that there is insufficient evidence to support the postulate that the association of cerebral aneurysms and developmental errors is significant. However, cerebral aneurysms frequently occur with polycystic disease of the kidneys and coarctation of the aorta, and these are the only two congenital diseases commonly associated with systemic hypertension. The coexistence of the lesions could be due to the concomitant hypertension and arterial degenerative disease rather than to hypothetical congenital factors.