ROLE OF ARTIFICIAL-VENTILATION, OXYGEN, AND CPAP IN PATHOGENESIS OF LUNG DAMAGE IN NEONATES - ASSESSMENT BY SERIAL MEASUREMENTS OF LUNG-FUNCTION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 57  (3) , 352-362
Abstract
Lung volume, airway resistance and compliance were measured in 19 infants, 18 of whom suffered from the respiratory distress syndrome (RDS) at birth, while the remaining infant was ventilated for persistent apnea and a pneumothorax. Prior to discharge from the neonatal unit, and after recovery from RDS, most infants had essentially normal lung function. When retested between 4 and 11 mo. of age, every infant who had received artificial ventilation during the acute illness developed a raised airway resistance, but the remaining infants, who were treated with continuous positive airway pressure and/or O2 were all entirely normal. The implications of these results for the management of RDS are discussed.

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