THE TREATMENT OF SERUM SICKNESS WITH BENADRYL

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Abstract
The recent report of State and Wangensteen1 was the first concerning the use of a drug having a satisfactorily specific therapeutic action in the treatment of serum sickness. They successfully employed intravenous injections of procaine hydrochloride to abolish the manifestations of serum sickness. In the past two years we have had an opportunity to observe the effect of Benadryl hydrochloride, a drug related to procaine, in the treatment of 10 patients with serum sickness. These patients responded to the oral administration of the drug. STUDY MATERIAL Serum sickness developed in our patients as a complication of serotherapy for a variety of conditions; 4 infants and 1 child from treatment with meningococcus antitoxin, a fairly crude horse serum preparation; 1 child from treatment with polyvalent antivenin, also a relatively crude horse serum preparation; 1 infant from treatment with diphtheria antitoxin, a more highly refined horse serum preparation, and 2 infants

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