The Clinical Significance of Cystitis Cystica in Girls: Results of a Prospective Study

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Abstract
Girls (22) with recurrent urinary tract infection and endoscopically proved cystitis cystica were studied prospectively to determine control of infection with long-term, continuous nitrofurantoin or sulfisoxazole (6-12 mo.), effect on the bladder changes and rate of recurrence of infection after discontinuation of medication. Infection was controlled equally with both drugs but, despite adequate control, 24% had evidence of cystic changes upon completion of the treatment period. An additional 44% became reinfected during the 1-yr followup with no drugs. Only 1/3 of those presenting with urinary frequency, urgency and urge incontinence had improvement of these symptoms with control of infection alone. Childhood cystitis cystica maybe the response of the bladder to long-term, inadequately treated bacterial lower urinary tract infection. Many months to years of continuous medication are required for healing.