Orthopoxvirus Strains Defective in Surface Antigen Induction

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Abstract
Various strains of vaccinia, variola, whitepox, monkeypox and cowpox viruses were examined for their capacity to induce a specific early antigen detectable on the surface of infected [chick embryo and cynomolgus monkey kidney] cells. The Elstree strain of vaccinia, 2 strains of variola minor and white variants of cowpox and monkeypox viruses lacked the capacity to induce the antigen. Variation of the parent cowpox and monkeypox viruses to white variants was always accompanied by the loss of the antigen-inducing capacity.

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