Modification of Ribosomes in Cryptopleurine-Resistant Mutants of Yeast
- 1 November 1973
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 116 (2) , 818-822
- https://doi.org/10.1128/jb.116.2.818-822.1973
Abstract
Cryptopleurine-resistant mutants of Saccharomyces cerevisiae were isolated. A single, recessive nuclear gene, very closely linked to the mating locus (2.1 centimorgans), is responsible for resistance. Ribosomes from the mutants were found to be resistant to cryptopleurine when analyzed by poly(U)-directed polyphenylalanine synthesis. Analysis of the distribution of ribosomes between monosomes and polysomes in sensitive cells exposed to cryptopleurine suggests that some step is inhibited during the elongation phase of protein synthesis.Keywords
This publication has 16 references indexed in Scilit:
- Mode of action of tylocrebrine: effects on protein and nucleic acid synthesis.1972
- Inhibitors of protein synthesis by ribosomes of the 80-S typeBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
- Formation of A ternary complex between yeast aminoacyl-tRNA binding factor, GTP, and aminoacyl-tRNABiochemical and Biophysical Research Communications, 1970
- [3] The biochemical genetics of yeastPublished by Elsevier ,1970
- Hydrolysis of guanosine 5'-triphosphate associated wh binding of aminoacyl transfer ribonucleic acid to ribosomes.1969
- Differentiation in vitro by phenanthrene alkaloids of yeast mitochondrial protein synthesis from ribosomal systems of both yeast and bacteriaBiochemical and Biophysical Research Communications, 1968
- Inhibition of protein synthesis in ehrlich ascites-tumour cells by the phenanthrene alkaloids tylophorine, tylocrebrine and cryptopleurineBiochemical and Biophysical Research Communications, 1968
- Aromatic Cyclodehydration. XXXVI.1,2 The Synthesis of (±)-CryptopleurineJournal of the American Chemical Society, 1958
- Structure of a Derivative of CryptopleurineNature, 1954
- Studies on the Biochemical Genetics of YeastProceedings of the National Academy of Sciences, 1949