Xmn I Polymorphism in the Gamma-Globin Gene Region among Saudis
- 31 December 1988
- journal article
- research article
- Published by S. Karger AG in Human Heredity
- Vol. 39 (1) , 12-19
- https://doi.org/10.1159/000153825
Abstract
The γ-globin chains of haemoglobin F are encoded by two non-allelic genes which synthesise two different γ-chains referred to as Gγ and Aγ. Xmn I restricts on both sides of the genes and normally produces an 8.1-kilobase (kb) fragment containing both γ-genes. A polymorphic site on the 5’ end of the Gγ genes has been reported in some populations and it results in the production of a 7.0-kb fragment containing both γ-genes.Keywords
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