Water-Mediated Catalyst Preactivation: An Efficient Protocol for C−N Cross-Coupling Reactions
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- 12 July 2008
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 10 (16) , 3505-3508
- https://doi.org/10.1021/ol801285g
Abstract
A protocol for forming a highly active Pd(0) catalyst from Pd(OAc)2, water, and biaryldialkylphosphine ligands has been developed. This protocol generates a catalyst system, which exhibits excellent reactivity and efficiency in the coupling of a variety of amides and anilines with aryl chlorides.Keywords
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