Total synthesis of prostaglandin D2 methyl ester
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 24,p. 1150-1152
- https://doi.org/10.1039/c39790001150
Abstract
The readily available norbornanone (2) gave a mixture of the lactones (3) and (4) on peracid oxidation, the minor component (4) being removed by treatment with aqueous alkali; conversion of (3) into (6) was performed so as to minimise silyl group scrambling, and the alcohol (6) was transformed into (±) prostaglandin D2 methyl ester (9) by oxidation followed by deprotection using HF in acetonitrile.Keywords
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