Production of Haemophilus influenzae b Meningitis in Infant Rats by Intraperitoneal Inoculation
- 1 August 1973
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 8 (2) , 278-290
- https://doi.org/10.1128/iai.8.2.278-290.1973
Abstract
Sprague-Dawley rats have a marked age-related susceptibility to Haemophilus influenzae type b that does not correlate with serum bactericidal activity. Eighty percent of 5-day-old animals that survive to 48 h after an intraperitoneal inoculation of a mean lethal dose of bacteria have histologically documented meningitis. Animals surviving the inoculations as infants manifest cerebral dysfunction as adults. This model should facilitate experimental study of bacterial meningitis.Keywords
This publication has 12 references indexed in Scilit:
- Human Serum Activities against Hemophilus influenzae, Type bJournal of Clinical Investigation, 1972
- Bacterial Meningitis — A Review of Selected AspectsNew England Journal of Medicine, 1965
- THE DETERMINATION OF DEOXYRIBONUCLEIC ACID AND OF CELL NUMBER IN BRAIN*Journal of Neurochemistry, 1964
- ACUTE BACTERIAL MENINGITIS.1964
- Complications of MeningitisAnnual Review of Medicine, 1963
- STUDIES ON THE PATHOGENESIS OF MENINGITIS. I. INTRATHECAL INFECTION*Journal of Clinical Investigation, 1962
- Mechanisms of Brain Damage in H. Influenzae MeningitisJournal of Neuropathology and Experimental Neurology, 1960
- Infectious meningo-encephalitis in cattle, caused by a haemophilus-like organism.1960
- The Fluorometric Measurement of Deoxyribonucleic Acid in Animal Tissues with Special Reference to the Central Nervous SystemJournal of Biological Chemistry, 1958
- Studies in Experimental Meningitis in Rhesus Monkeys I. The Pathogenic Effect of Various Bacteria Recovered from Human CasesThe Journal of Infectious Diseases, 1955