Choleretic Effect of Picroliv, the Hepatoprotective Principle ofPicrorhiza kurroa1
- 1 February 1991
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 57 (01) , 29-33
- https://doi.org/10.1055/s-2006-960010
Abstract
Picroliv, the hepatoprotective principle of the plant Picrorhiza kurroa, showed a dose-dependent (1.5 - 12 mg/kg × 7) choleretic effect in conscious rats and anaesthetised guinea pigs. It also possessed a marked anticholestatic effect against paracetamol- and ethynylestradiol-induced cholestasis. It antagonised the changes in bile volume as well as the contents (bile salts and bile acids). Silymarin, a known hepatoprotective agent, was tested simultaneously for comparison. Picroliv was found to be a more potent choleretic and anticholestatic agent than silymarin.Keywords
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