INCREASED PRIMARY CELL-MEDIATED-IMMUNITY IN CULTURE SUBSEQUENT TO ADRIAMYCIN OR DAUNORUBICIN TREATMENT OF SPLEEN DONOR MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (6) , 1719-1726
Abstract
Spleen cell populations from mice treated with adriamycin or daunorubicin developed a greater complement-independent cellular cytotoxic immune response during culture with allogeneic tumor cells [P-815 mastocytoma, L1210 and EL4 leukemias, 6C3HED thymoma] than spleen cells from untreated or cyclophosphamide-treated animals. A temporal and drug dose dependence of this effect was demonstrated. The changes in spleen cell population occurring in the donor mice consequent to drug treatment were evident in the nylon wool-adherent fraction of the spleen cells. The concentration of specific progenitor or accessory cells in the spleen is probably increased consequent to drug treatment.

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