Ovarian Cancer
Top Cited Papers
- 1 February 2009
- journal article
- review article
- Published by Annual Reviews in Annual Review Of Pathology-Mechanisms Of Disease
- Vol. 4 (1) , 287-313
- https://doi.org/10.1146/annurev.pathol.4.110807.092246
Abstract
Ovarian carcinomas are a heterogeneous group of neoplasms and are traditionally subclassified based on type and degree of differentiation. Although current clinical management of ovarian carcinoma largely fails to take this heterogeneity into account, it is becoming evident that each major histological type has characteristic genetic defects that deregulate specific signaling pathways in the tumor cells. Moreover, within the most common histological types, the molecular pathogenesis of low-grade versus high-grade tumors appears to be largely distinct. Mouse models of ovarian carcinoma have been developed that recapitulate many of the morphological features, biological behavior, and gene-expression patterns of selected subtypes of ovarian cancer. Such models will likely prove useful for studying ovarian cancer biology and for preclinical testing of molecularly targeted therapeutics, which may ultimately lead to better clinical outcomes for women with ovarian cancer.Keywords
This publication has 144 references indexed in Scilit:
- Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesisAmerican Journal of Obstetrics and Gynecology, 2008
- DNA profiling of primary serous ovarian and Fallopian tube carcinomas with array comparative genomic hybridization and multiplex ligation‐dependent probe amplificationThe Journal of Pathology, 2007
- Digital karyotypingNature Protocols, 2007
- p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor GenesPublished by Elsevier ,2007
- Clinical and biological significance of HLA-G expression in ovarian cancerSeminars in Cancer Biology, 2007
- Amplicon profiles in ovarian serous carcinomasInternational Journal of Cancer, 2007
- Testing of two binary grading systems for FIGO stage III serous carcinoma of the ovary and peritoneumGynecologic Oncology, 2006
- Perturbations of the AKT signaling pathway in human cancerOncogene, 2005
- Cancer genes and the pathways they controlNature Medicine, 2004
- Histologic Transformation of Benign Endometriosis to Early Epithelial Ovarian CancerGynecologic Oncology, 1996