ADRENALIN AND BLOOD LACTIC ACID: EFFECT OF EVISCERATION

Publisher Website
Google Scholar
Abstract
Cats during the 2d hr. after admin. of chloralose had a steady or slightly falling blood lactic acid level, av. 9.6 mgm. % after 5-min. intraven. inj. of adrenalin at rates between 0.001 and 0.004 mgm. per kilo per minute, this increased to 12.7, and in the next 10 mins. to 14.3; in 30 mins. it had fallen to 13.1 mgm. %. Failure to produce a detectable rise occurred only once in 51 expts. During the 2d hr. after evisceration blood lactic acid rose at the rate of 0.235 mgm. % per min., reaching an av. of 27.9 mgm. %. Inj. of adrenalin (as above) had no effect in 3, produced only a slight transient increase in 9, and in 21 expts. a decrease in blood lactic acid. Variations were from 5 to 48, avg.,[long dash]17%. The current explanation of adrenalin lactacidemia as due to augmented glycolysis of skeletal muscle probably needs revision. The viscera are a potential source of blood lactic acid in the intact animals; blood glycolysis, reciprocally related to respiration, is a possible factor in the variations observed after evisceration.