INFLUENCE OF ANAESTHETIC AGENTS ON THE SURVIVAL OF RATS FOLLOWING ACUTE ISCHAEMIA OF THE BOWEL

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Abstract
The effects of ketamine and halothane anesthesia on the survival of rats subjected to superior mesenteric artery occlusion were studied. Survival was significantly greater with halothane. Animals anesthetized with ketamine developed arterial hypocarbia during bowel ischemic shock, but those receiving halothane did not. Arterial hypoxemia was not present in either group. Hematocrits increased in both groups after bowel ischemia. Excess lactate was increased significantly in non-survivors compared with survivors. The survival data contrast with previous results obtained after hemorrhagic hypotension and emphasize the need to consider differing therapeutic approaches in the various shock states.