High Levels of IgA‐Containing Circulating Immune Complex and Secretory IgA in Kawasaki Disease

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Abstract
Sera of patients with Kawasaki disease were studied for the levels of IgA‐containing (C3‐fixing) circulating immune complexes (IgA‐CIC), IgG‐containing (IgG‐) CIC, total IgA, secretory IgA, and complement component (C3) by means of enzyme‐linked immunosorbent assays or single radial immunodiffusion methods. There was significantly high level of IgA‐CIC, but not IgG‐CIC. The levels of total IgA, secretory IgA, and C3 were significantly elevated. Significantly high levels of secretory IgA were found in 22 (51%) of 43 patients. The proportion of secretory IgA to total IgA also increased. These abnormalities in the IgA system may play a role in Kawasaki disease.