Prognostic factors in stage AO B‐cell chronic lymphocytic leukaemia

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Abstract
Summary: 85 patients presenting to a single centre with stage AO B‐cell chronic lymphocytic leukaemia (B‐CLL) have been studied. The duration of follow‐up has ranged from a minimum of 1 year to a maximum of 18 years with a mean of 6 years.14 patients have had progressive disease and 23 patients have died, of whom nine had CLL‐related deaths. We assessed the prognostic significance of the following parameters: age at presentation, sex, haemoglobin concentration, initial lymphocyte count, surface membrane phenotype. serum immunoglobulin levels at presentation and karyotype.None of these factors were predictive of survival, but there was a correlation between initial lymphocyte count, surface immunoglobulin MDλ phenotype, and complex karyotypic abnormalities and disease progression.Two patients with a complex karyotype have been followed for more than 5 years without evidence of progression.