[Antimicrobial susceptibility of a selection of Salmonella enterica strains of various origins isolated in Spain].

  • 1 September 1999
    • journal article
    • abstracts
    • Vol. 12  (3) , 250-4
Abstract
The widespread use of antimicrobials in human and veterinary practice is increasingly causing the emergence of different multidrug-resistant human pathogens. This situation makes treating infections caused by these microorganisms difficult. Salmonella enterica is an ubiquitous organism and may be a good indicator of the influence of the use and abuse of antimicrobials on the appearance of multiresistant strains. One hundred and ninety S. enterica strains of different origins isolated in Spain in 1996 were randomly selected. The minimal inhibitory concentration (MIC) was studied using the agar dilution method according to NCCLS criteria in the following antimicrobials: ampicillin, ticarcillin, amoxicillin-clavulanic acid, cefazolin, cefuroxime, cefotaxime, imipenem, gentamicin, apramycin, ciprofloxacin, streptomycin, chloramphenicol, tetracycline, sulfamethoxazole and co-trimoxazole. Sixty-three percent of the S. enterica tested were resistant and 24% were multiresistant. The percentage of resistant and multiresistant strains of S. enterica of human origin was slightly higher than those of nonhuman origin. Statistically, ampicillin, ticarcillin and amoxicillin-clavulanic acid were significantly more resistant in strains of human origin. Ninety-one percent of the strains of Typhimurium serotype and phagotype 104 were multiresistant. The Salmonella Typhimurium serotype and phagotype 104 ACSTSu-resistant clone, which is widespread in various Western countries, was also isolated in this study. The use of different antimicrobials in human and veterinary practice needs to be rationalized.

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