MODIFICATION, BY ASPIRIN AND INDOMETHACIN, OF THE HAEMODYNAMIC AND PROSTAGLANDIN RELEASING EFFECTS OF E. coli ENDOTOXIN IN THE DOG

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Abstract
1 Dogs treated with aspirin (10 mg/kg) or indomethacin (1.5 mg/kg) 45 min before, and 3 h after, an LD50 dose (1 mg/kg) of E. coli endotoxin were alive 72 h later. 2 Although all dogs in both treated groups survived, only those treated with indomethacin were protected against the fall in blood pressure 1–2 min following endotoxin. 3 Endotoxin increased the level of prostaglandin F2α in both the mixed venous and arterial blood. No increase was observed in the aspirin and indomethacin-treated groups. 4 Aspirin and indomethacin treatment did not modify thrombocytopaenia or blood coagulation parameters following endotoxin.