Measurement of Procarboxypeptidase U (TAFI) in Human Plasma: A Laboratory Challenge
- 1 January 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 52 (1) , 30-36
- https://doi.org/10.1373/clinchem.2005.055814
Abstract
Background: The importance of carboxypeptidase U (CPU) as a novel regulator of the fibrinolytic rate has attracted much interest during recent years. CPU circulates in plasma as a zymogen, proCPU, that can be activated by thrombin, thrombin-thrombomodulin (T-Tm), or plasmin. Given that the proCPU concentration in plasma is far below its Km for activation by the T-Tm complex, the formation of CPU will be directly proportional to the proCPU concentration. A low or high proCPU plasma concentration might therefore tip the balance between profibrinolytic and antifibrinolytic pathways and thereby cause a predisposition to bleeding or thrombosis.Keywords
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