Newer concepts of atopic dermatitis
- 1 May 1977
- journal article
- review article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 113 (5) , 663-670
- https://doi.org/10.1001/archderm.113.5.663
Abstract
Atopic dermatitis is a [human] disease characterized by abnormalities related to both type 1 and type 4 immune responses, yet the skin lesions cannot be classified under either of these reaction types. The disease is difficult to define; diagnosis depends on a combination of morphologic, distributional and historical features. Skin lesions typical of atopic dermatitis are seen in a number of immune deficiency conditions, especially those characterized by depressed cell-mediated immunity, elevated IgE[immunoglobulin]E production and in some instances IgA deficiency suggesting a common disorder in the ontogeny of immunoglobulin-producing cells. Defective T [thymus-derived] lymphocyte mediation of the B [bone marrow-derived] lymphocytes producing these immunoglobulins may explain the combined cellular and humoral abnormalities observed. Homologies between T cells and epidermal cells could account for the combined immunologic and cutaneous defects seen in atopic dermatitis.This publication has 19 references indexed in Scilit:
- Incidence of Contact Sensitivity in Atopic DermatitisArchives of Dermatology, 1964
- Immune Globulin Determinations in Allergic ChildrenArchives of Pediatrics & Adolescent Medicine, 1963
- Wheal and erythema allergy in patients with agammaglobulinemiaJournal of Allergy, 1962
- THE CONTROL OF MITOTIC ACTIVITY IN ADULT MAMMALIAN TISSUESBiological Reviews, 1962
- VASCULAR SKIN REACTION IN ATOPIC DERMATITIS1962
- Skin Reactions to Iontophoretically Administered Epinephrine and Norepinephrine in Atopic Dermatitis11From the Department of Dermatology, University of Uppsala, Uppsala, Sweden and the Department of Dermatology, University of Pennsylvania, School of Medicine, Philadelphia 4, Pa.Journal of Investigative Dermatology, 1961
- Studies on the Mechanism of the White Response and of the Delayed Blanch Phenomenon in Atopic Subjects by Means of Coomassie Blue**From the Section of Dermatology, Department of Medicine Royal Victoria Hospital, McGill University, Montreal, P.Q. Canada.Read in part at the Annual Meeting of the Canadian Dermatological Association on June 6th, 1959, in Montreal, Quebec.Journal of Investigative Dermatology, 1960
- THE NATURE OF ITCHING IN DERMATITIC SKINAnnals of Internal Medicine, 1958
- Observations on the Delayed Blanch Phenomenon in Atopic Subjects11From the Department of Dermatology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Wash. 12, D. C. and Dermatology Service, Walter Reed Army Hospital, Walter Reed Army Medical Center, Wash. 12, D. C.Journal of Investigative Dermatology, 1958
- Further Contributions to the Vascular Physiology of Atopic Dermatitis11The Mayo Foundation is a part of the Graduate School of the University of Minnesota.Read at the meeting of the Society for Investigative Dermatology, San Francisco, California, June 19, 1954.Journal of Investigative Dermatology, 1955