Aging and endothelin-1 induced vascular contractions
- 1 October 1990
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 46 (10) , 1008-1009
- https://doi.org/10.1007/bf01940656
Abstract
Contractions produced by endothelin-1 (0.3–30 nM) have been investigated in aorta, renal arteries and mesenteric arteries from 2- and 24-month-old Sprague-Dawley rats. In senescent rats the EC50 values of endothelin-1 for aorta and renal artery were significantly increased (aorta: from 6.2 to 12 nM; renal artery: from 5.2 to 7.8 nM). For mesenteric artery the EC50 value (4.3 nM) was unchanged by aging, whereas the maximal contractile response to endothelin-1 was enhanced (from 8.3 to 11.7 mN). In contrast, there was no significant age-related difference in the maximal endothelin-1 response of aorta and renal artery. The present data demonstrate a reduced sensitivity for aorta and renal artery and an enhanced maximal response to endothelin-1 in the mesenteric artery in senescent rats.This publication has 5 references indexed in Scilit:
- Immunoreactive Endothelin-1 in Plasma Detected by a Sandwich-Type Enzyme ImmunoassayJournal of Cardiovascular Pharmacology, 1989
- A novel potent vasoconstrictor peptide produced by vascular endothelial cellsNature, 1988
- Aging and vascular responsiveness.1988
- Aging and Vascular ResponsivenessJournal of Cardiovascular Pharmacology, 1988
- Changes in Vascular Smooth Muscle Reactivity During DevelopmentAnnual Review of Pharmacology and Toxicology, 1984